To create a radiograph, a patient is positioned so that the part of the body being imaged is located between an x-ray source and an x-ray detector. When the machine is turned on, x-rays travel through the body and are absorbed in different amounts by different tissues, depending on the radiological density of the tissues they pass through. Radiological density is determined by both the density and the atomic number (the number of protons in an atom's nucleus) of the materials being imaged. For example, structures such as bone contain calcium, which has a higher atomic number than most tissues. Because of this property, bones readily absorb x-rays and, thus, produce high contrast on the x-ray detector. As a result, bony structures appear whiter than other tissues against the black background of a radiograph. Conversely, x-rays travel more easily through less radiologically dense tissues such as fat and muscle, as well as through air-filled cavities such as the lungs. These structures are displayed in shades of gray on a radiograph.

Combines traditional x-ray technology with computer processing to generate a series of cross-sectional images of the body that can later be combined to form a three-dimensional x-ray image. CT images are more detailed than plain radiographs and give doctors the ability to view structures within the body from many different angles.

A radiograph of the breast that is used for cancer detection and diagnosis. Tumors tend to appear as regular or irregular-shaped masses that are somewhat brighter than the background on the radiograph (i.e., whiter on a black background or blacker on a white background). Mammograms can also detect tiny bits of calcium, called microcalcifications, which show up as very bright specks on a mammogram. While usually benign, microcalcifications may occasionally indicate the presence of a specific type of cancer.